地中海食と 2 型糖尿病発症の栄養バイオマーカー スコア: MedLey ランダム化対照試験と EPIC からのデータの統合分析

6 h), current use of vitamin or mineral supplements, marital status (single, married or cohabiting, divorced or separated, and widowed), educational attainment (none, primary school, technical or professional school, secondary school, and post-secondary school education), current employment, and in women, menopausal status (pre-, peri-, postmenopausal, and bilateral oophorectomy) and current hormone replacement therapy use. A further model was fitted with adjustment for adiposity (BMI and waist circumference as continuous variables; main analytical model). Additional models explored the effects of adjustment for biomarkers constituting the biomarker score. Continuous covariates were Winsorised at 4 SDs below or above the subcohort means. For comparison with the biomarker-based assessment, we estimated the HR for the association with incident T2D of the standardised score of self-reported Mediterranean diet using the main analytical model./p>

6 h), current use of vitamin or mineral supplements, marital status (single, married or cohabiting, divorced or separated, widowed), educational attainment (none, primary school, technical or professional school, secondary school, post-secondary school education), current employment, body mass index and waist circumference, and in women, menopausal status (pre-, peri-, postmenopausal, bilateral oophorectomy) and current hormone replacement therapy use. CI, confidence interval; HR, hazard ratio; SD, standard deviation; T2D, type 2 diabetes./p>

60 years were 0.54 (0.42 to 0.69), 0.74 (0.69 to 0.80), and 0.74 (0.67 to 0.82), respectively. The results from complete-case analysis were similar to the multiple imputation estimates (S6 Table). The HR (95% CI) per 1 SD of the score of self-reported Mediterranean diet was 0.90 (0.86 to 0.95)./p>